Rate of Cognitive Decline in Alzheimer’s Disease Stratified by Age
نویسندگان
چکیده
منابع مشابه
Age and rate of cognitive decline in Alzheimer disease: implications for clinical trials.
BACKGROUND Factors that affect the rate of progression of Alzheimer disease (AD) need to be considered in the clinical trial designs of potential disease-modifying therapies. OBJECTIVE To determine the influence of age on AD course in a clinical trial setting. DESIGN Pooled cohort study from 3 AD clinical trials of 18-month duration conducted by the Alzheimer Disease Cooperative Study group...
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OBJECTIVES To measure the rate and predictors of change on the Mini-Mental State Examination in patients with Parkinson disease (PD) and to compare that change with the Mini-Mental State Examination changes of patients with Alzheimer disease and nondemented subjects. PATIENTS Patients with PD were drawn from a community-based cohort in Rogaland County, Norway. Those who were without cognitive...
متن کاملAge-associated cognitive decline.
INTRODUCTION Age-associated cognitive decline-or normal (non-pathological, normative, usual) cognitive ageing-is an important human experience which differs in extent between individuals. The determinants of the differences in age-related cognitive decline are not fully understood. Progress in the field is taking place across many areas of biomedical and psychosocial sciences. AREAS OF AGREEM...
متن کاملExplorer Age - associated cognitive decline
General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edin...
متن کاملAPOE interacts with age to modify rate of decline in cognitive and brain changes in Alzheimer's disease.
OBJECTIVE To determine (1) whether age-standardized cognitive declines and brain morphometric change differ between Young-Old patients with Alzheimer's disease (YOAD) and Very-Old patients with Alzheimer's disease (VOAD), and (2) whether the apolipoprotein E (APOE) genotype modifies these neuropsychological and morphometric changes. METHODS Baseline and 12-month follow-up neuropsychological a...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2019
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-181047